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Inhibitors

Patient information

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An inhibitor is an antibody that reduces the ability of a factor VIII product to control bleeding.

Antibodies are part of the immune system. They recognise foreign proteins and destroy them in order to protect the body from disease. Unfortunately, antibodies occasionally perceive natural proteins as foreign, and destroy them.

Some people with severe haemophilia develop antibodies against factor VIII. The antibodies destroy the factor VIII, reducing the efficacy of treatment.

The formation of inhibitors to factor VIII is a known complication in the management of individuals with haemophilia A. In studies with recombinant factor VIII products, development of inhibitors occurs predominantly in previously untreated patients.

What is the chance that I will get an inhibitor?

Antibodies recognise foreign proteins by fitting together with them

Produced by Bayer. This website is intended for residents of the UK.
Date of preparation: December 2010 UK.PH.HN.KOG.2010.250.77.4